Validation of the MDS-UPDRS Part I for nonmotor symptoms in Parkinson's disease.
Identifieur interne : 000B57 ( Main/Exploration ); précédent : 000B56; suivant : 000B58Validation of the MDS-UPDRS Part I for nonmotor symptoms in Parkinson's disease.
Auteurs : David A. Gallagher [Royaume-Uni] ; Christopher G. Goetz ; Glenn Stebbins ; Andrew J. Lees ; Anette SchragSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Activities of Daily Living, Aged, Behavioral Symptoms (diagnosis), Behavioral Symptoms (etiology), Cognition Disorders (diagnosis), Cognition Disorders (etiology), Constipation (diagnosis), Constipation (etiology), Disability Evaluation, Factor Analysis, Statistical, Female, Humans, Male, Middle Aged, Pain Measurement, Parkinson Disease (complications), Parkinson Disease (diagnosis), Psychometrics, Quality of Life, Reproducibility of Results, Severity of Illness Index, Sleep Disorders (diagnosis), Sleep Disorders (etiology), Societies, Medical (standards), Statistics, Nonparametric, Urinary Bladder Diseases (diagnosis), Urinary Bladder Diseases (etiology).
- MESH :
- complications : Parkinson Disease.
- diagnosis : Behavioral Symptoms, Cognition Disorders, Constipation, Parkinson Disease, Sleep Disorders, Urinary Bladder Diseases.
- etiology : Behavioral Symptoms, Cognition Disorders, Constipation, Sleep Disorders, Urinary Bladder Diseases.
- standards : Societies, Medical.
- Activities of Daily Living, Aged, Disability Evaluation, Factor Analysis, Statistical, Female, Humans, Male, Middle Aged, Pain Measurement, Psychometrics, Quality of Life, Reproducibility of Results, Severity of Illness Index, Statistics, Nonparametric.
Abstract
The UPDRS has been the main outcome measure in studies of PD. Modifications have been made to improve scale properties and represent the breadth of manifestations of PD, particularly nonmotor symptoms (NMS), resulting in the Movement Disorder Society's revision of the UPDRS (MDS-UPDRS). This study was undertaken to determine the validity of MDS-UPDRS Part I (nonmotor experiences of daily living). The MDS-UPDRS and a number of validated scales for the NMS in PD were used in 94 patients with PD from Hoehn and Yahr stage I to V. We assessed reliability, floor and ceiling effects, and correlations with validated scales for the nonmotor symptoms of PD. MDS-UPDRS Part I showed high internal consistency (Cronbach's alpha: 0.85), small floor and ceiling effects (2% floor and 0% ceiling effect), and good concurrent validity (correlation with the original UPDRS Part I: r = 0.81, P < 0.001). The standardized z-score of the MDS-UPDRS Part I score demonstrated high convergent validity with the composite z-score of nonmotor scales (r = 0.89, P < 0.0001), and the two subscores based on the original factor analysis of Part I also had high correlations with the composite z-scores of corresponding nonmotor scales (depression, anxiety, apathy factor score: r = 0.72, P < 0.0001; other nonmotor features factor score: r = 0.87, P < 0.0001). Our data demonstrate that the MDS-UPDRS Part I total score has a strong relationship with a composite score of validated scales for the nonmotor aspects of PD.
DOI: 10.1002/mds.23939
PubMed: 21915909
Affiliations:
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Goetz</name></author><author><name sortKey="Stebbins, Glenn" sort="Stebbins, Glenn" uniqKey="Stebbins G" first="Glenn" last="Stebbins">Glenn Stebbins</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name></author><author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.23939</idno><idno type="RBID">pubmed:21915909</idno><idno type="pmid">21915909</idno><idno type="wicri:Area/PubMed/Corpus">001051</idno><idno type="wicri:Area/PubMed/Curation">001051</idno><idno type="wicri:Area/PubMed/Checkpoint">000B64</idno><idno type="wicri:Area/Ncbi/Merge">003379</idno><idno type="wicri:Area/Ncbi/Curation">003379</idno><idno type="wicri:Area/Ncbi/Checkpoint">003379</idno><idno type="wicri:Area/Main/Merge">000B58</idno><idno type="wicri:Area/Main/Curation">000B57</idno><idno type="wicri:Area/Main/Exploration">000B57</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Validation of the MDS-UPDRS Part I for nonmotor symptoms in Parkinson's disease.</title><author><name sortKey="Gallagher, David A" sort="Gallagher, David A" uniqKey="Gallagher D" first="David A" last="Gallagher">David A. Gallagher</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Neurology, University College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Neurology, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G" last="Goetz">Christopher G. Goetz</name></author><author><name sortKey="Stebbins, Glenn" sort="Stebbins, Glenn" uniqKey="Stebbins G" first="Glenn" last="Stebbins">Glenn Stebbins</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name></author><author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Behavioral Symptoms (diagnosis)</term><term>Behavioral Symptoms (etiology)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (etiology)</term><term>Constipation (diagnosis)</term><term>Constipation (etiology)</term><term>Disability Evaluation</term><term>Factor Analysis, Statistical</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pain Measurement</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Psychometrics</term><term>Quality of Life</term><term>Reproducibility of Results</term><term>Severity of Illness Index</term><term>Sleep Disorders (diagnosis)</term><term>Sleep Disorders (etiology)</term><term>Societies, Medical (standards)</term><term>Statistics, Nonparametric</term><term>Urinary Bladder Diseases (diagnosis)</term><term>Urinary Bladder Diseases (etiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Behavioral Symptoms</term><term>Cognition Disorders</term><term>Constipation</term><term>Parkinson Disease</term><term>Sleep Disorders</term><term>Urinary Bladder Diseases</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Behavioral Symptoms</term><term>Cognition Disorders</term><term>Constipation</term><term>Sleep Disorders</term><term>Urinary Bladder Diseases</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Societies, Medical</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Aged</term><term>Disability Evaluation</term><term>Factor Analysis, Statistical</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Pain Measurement</term><term>Psychometrics</term><term>Quality of Life</term><term>Reproducibility of Results</term><term>Severity of Illness Index</term><term>Statistics, Nonparametric</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The UPDRS has been the main outcome measure in studies of PD. Modifications have been made to improve scale properties and represent the breadth of manifestations of PD, particularly nonmotor symptoms (NMS), resulting in the Movement Disorder Society's revision of the UPDRS (MDS-UPDRS). This study was undertaken to determine the validity of MDS-UPDRS Part I (nonmotor experiences of daily living). The MDS-UPDRS and a number of validated scales for the NMS in PD were used in 94 patients with PD from Hoehn and Yahr stage I to V. We assessed reliability, floor and ceiling effects, and correlations with validated scales for the nonmotor symptoms of PD. MDS-UPDRS Part I showed high internal consistency (Cronbach's alpha: 0.85), small floor and ceiling effects (2% floor and 0% ceiling effect), and good concurrent validity (correlation with the original UPDRS Part I: r = 0.81, P < 0.001). The standardized z-score of the MDS-UPDRS Part I score demonstrated high convergent validity with the composite z-score of nonmotor scales (r = 0.89, P < 0.0001), and the two subscores based on the original factor analysis of Part I also had high correlations with the composite z-scores of corresponding nonmotor scales (depression, anxiety, apathy factor score: r = 0.72, P < 0.0001; other nonmotor features factor score: r = 0.87, P < 0.0001). Our data demonstrate that the MDS-UPDRS Part I total score has a strong relationship with a composite score of validated scales for the nonmotor aspects of PD.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><noCountry><name sortKey="Goetz, Christopher G" sort="Goetz, Christopher G" uniqKey="Goetz C" first="Christopher G" last="Goetz">Christopher G. Goetz</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew J. Lees</name><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name><name sortKey="Stebbins, Glenn" sort="Stebbins, Glenn" uniqKey="Stebbins G" first="Glenn" last="Stebbins">Glenn Stebbins</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gallagher, David A" sort="Gallagher, David A" uniqKey="Gallagher D" first="David A" last="Gallagher">David A. Gallagher</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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